VIP Peptide Specifications

Core Identifiers

Name: Vasoactive Intestinal Peptide (VIP)
Full chemical name: H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-OH
Synonyms: Vasoactive intestinal polypeptide; VIP
Sequence (1-letter): HSDAVFTDNYTRLRKQMAVKKYLNSILN
Sequence (3-letter): His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn

Physicochemical Data

CAS Number: 37221-79-7
Molecular formula: C₁₄₇H₂₃₈N₄₄O₄₂S
Molecular weight: 3325.8 g/mol
Peptide length: 28 amino acids
Family: Glucagon/secretin superfamily peptide hormone

Biological Context

Endogenous source: Expressed in multiple tissues including gut, pancreas, and central nervous system (notably the suprachiasmatic nucleus).
Receptors: Acts primarily via VPAC1 and VPAC2 class II G protein–coupled receptors.
Endogenous roles: Regulation of vasodilation, cardiac contractility, smooth muscle relaxation, gastrointestinal secretion and motility, and circadian signaling.

Research Focus (Non-Clinical)

VIP is under active investigation as a multifunctional neuropeptide with roles in vascular tone, gastrointestinal physiology,
immune regulation, and neuroendocrine signaling. Research models have explored its ability to modulate mucosal inflammation,
epithelial barrier integrity, and Th1/Th2 balance, as well as its potential impact on glycemic control and tumor biology.

Preclinical and early translational studies are evaluating VIP and VIP-analogues in settings such as inflammatory bowel disease,
colitis models, primary pulmonary hypertension, autoimmune and rheumatologic disease, and selected neurodegenerative and lung
disorders. All such work remains experimental and is confined to controlled laboratory and preclinical research environments.

Technical Description

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid peptide (HSDAVFTDNYTRLRKQMAVKKYLNSILN) belonging to the glucagon/secretin
superfamily. It is supplied as a research-grade peptide for in vitro use and other approved laboratory applications only.

All products are intended for laboratory research use only. Not for human consumption,
veterinary, or household use.