SLU-PP-332

SLU-PP-332 is a synthetic small-molecule research compound characterized as a potent, non-selective estrogen-related receptor (ERR) pan-agonist with the highest affinity for ERRα. It is widely used in preclinical studies exploring energy metabolism, mitochondrial function, and exercise-mimetic signaling pathways.

Product Information

CAS Number: 303760-60-3
Chemical Name: (E)-4-Hydroxy-N’-(naphthalen-2-ylmethylene)benzohydrazide
Molecular Formula: C18H14N2O2
Molecular Weight: 290.32 g/mol
Synonyms: SLU-PP-332; SLU PP 332
Purity: ≥ 98% (HPLC) – typical research grade specification
Appearance: Clear Liquid
Storage Conditions: Store at -20°C, protected from light and moisture; keep container tightly closed.

Research Profile

SLU-PP-332 functions as an ERR pan-agonist, displaying EC50 values in the low nanomolar range for ERRα, ERRβ, and ERRγ, with the greatest potency at ERRα. In cellular and animal models, it has been reported to enhance mitochondrial biogenesis, increase fatty acid oxidation, and support an acute aerobic exercise-like response, making it of interest as an exercise mimetic and metabolic research tool.

This compound is suitable for in vitro or in vivo experimental systems investigating pathways related to energy expenditure, obesity, insulin sensitivity, and skeletal muscle endurance. Researchers commonly use SLU-PP-332 to probe ERR-dependent transcriptional networks and to model the metabolic effects of enhanced mitochondrial activity.

Formulation and Solubility

Solubility (in vitro): Readily soluble in DMSO, with reported solubility up to approximately 125 mg/mL (~430 mM).
Suggested Solvents: DMSO for stock solutions; further dilution into aqueous buffers or vehicles as appropriate for the assay.
Handling: Allow vial to reach room temperature before opening, minimize exposure to air and moisture, and avoid repeated freeze–thaw cycles.

Intended Use

This material is supplied for laboratory research use only and is not intended for human or veterinary use, clinical applications, diagnostic procedures, or household purposes. All handling and disposal should follow appropriate laboratory safety guidelines and institutional regulations for chemical research materials.