PT-141 (Bremelanotide) (Research Use Only)

Name: PT-141
SKU: 529
Availability: InStock

Chemical Name: Bremelanotide (PT-141)

CAS Number:
852681-05-5

Molecular Formula: C₅₀H₆₈N₁₄O₁₀

Molecular Weight: 1039.30 g/mol

Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH

Appearance: White to off-white powder

Storage: Store at 2–8°C, protect from light and moisture

Form: Lyophilized powder; soluble in sterile water or DMSO

Description

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide and melanocortin receptor agonist derived from Melanotan II. It is primarily researched for its ability to stimulate sexual arousal by activating melanocortin receptors in the central nervous system, distinct from traditional phosphodiesterase inhibitors. PT-141 shows promise in studies focused on sexual dysfunction and libido enhancement.
(Wikipedia)
(PubChem)

Research Applications

Mechanistic studies of melanocortin receptor-mediated sexual arousal
Development of therapies for hypoactive sexual desire disorder
Investigation of central nervous system pathways regulating libido
Exploration of non-hormonal treatments for sexual dysfunction

Key References

Mechanism of Action

PT-141 activates melanocortin receptors, particularly MC3R and MC4R, in the central nervous system to modulate sexual arousal and behavior. Its mechanism is independent of the vascular pathways targeted by other therapies, offering an alternative approach focused on neurological stimulation.

Safety and Handling

Store PT-141 lyophilized powder at 2–8°C with moisture protection. Prepare fresh solutions under sterile conditions prior to research use. Studies report favorable safety profiles in preclinical models, with transient side effects.

Disclaimer

For laboratory research use only. Not for human, veterinary, medical, or diagnostic use. All information provided for scientific and educational purposes only.