Epithalon (Epitalon) (Research Use Only)
Chemical Name: Epithalon (Ala-Glu-Asp-Gly)
CAS Number:
307297-39-8
Molecular Formula: C14H22N4O9
Molecular Weight: 390.35 g/mol
Sequence: Ala-Glu-Asp-Gly
Appearance: White to off-white powder
Storage: Store lyophilized powder at −20°C, protect from moisture and light
Form: Lyophilized peptide powder, soluble in DMSO or water
Description
Epithalon (also known as Epitalon) is a synthetic tetrapeptide derived from a naturally occurring polypeptide produced in the pineal gland. It is widely researched for its potential anti-aging, geroprotective, and telomerase-activating properties. Epithalon has demonstrated capabilities in regulating circadian and hormonal rhythms, promoting telomere elongation, reducing oxidative stress, and supporting DNA repair mechanisms.
(Wikipedia)
(PubChem)
Research Applications
- Telomerase activation and telomere length regulation studies
- Anti-aging and longevity research
- Epigenetic regulation and chromatin remodeling
- Oxidative stress reduction and antioxidant gene expression
- Neuroendocrine modulation and melatonin synthesis support
- Wound healing and fibrotic programming investigations
Key References
Mechanism of Action
Epithalon stimulates telomerase activity leading to telomere elongation and cellular lifespan extension in vitro. It influences melatonin synthesis regulation, antioxidant gene expression (SOD2, CAT, HMOX1), and modulates epigenetic marks affecting genome stability, potentially reducing cellular senescence and promoting regenerative phenotypes.
Safety and Handling
Store Epithalon lyophilized powder at −20°C protected from moisture. Reconstitute immediately before research use. Experimental studies report minimal toxicity and favorable safety profiles in preclinical models.
Disclaimer
For laboratory research use only. Not for human, veterinary, medical, or diagnostic application. All information is provided for research and educational purposes.
| Weight | N/A |
|---|---|
| Dimensions | N/A |
| Epithalonmg | 10mg, 50mg |
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