Thymosin Alpha-1 (Research Use Only)

Chemical Name: Thymosin Alpha-1 (Thymalfasin)

CAS Number:
62304-98-7

Molecular Formula: C₁₂₉H₂₁₅N₃₃O₅₅

Molecular Weight: 3108.28 g/mol

Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH

Appearance: White to off-white sterile lyophilized powder

Storage: Store at −20°C in a dry place, protected from light

Form: Lyophilized peptide powder; soluble in water or sterile buffer

Description

Thymosin Alpha-1 is a synthetic 28-amino acid peptide closely related to the thymic hormone involved in the regulation and enhancement of immune function. It is studied for its immunomodulatory properties, including stimulation of T-cell and dendritic cell responses, enhancement of cytokine production, and protective effects against infections and cancer. Thymosin Alpha-1 has demonstrated potential in reducing toxicity from chemotherapy and supporting immune reconstitution in immunocompromised models.
(Wikipedia)
(PubChem)

Research Applications

Immune system enhancement and immunomodulation
Support in infectious disease and viral models
Reduction of chemotherapy-induced toxicity
Potential treatment for cancers and chronic infections
Studies on T-cell activation and cytokine regulation

Key References

Mechanism of Action

Thymosin Alpha-1 enhances immune response by modulating T-lymphocyte function, dendritic cell maturation, and cytokine expression. It promotes immune surveillance and repair processes, contributing to its antiviral, anticancer, and immunoregulatory effects.

Safety and Handling

Store lyophilized Thymosin Alpha-1 powder at −20°C, protected from moisture and light. Reconstitute in sterile water or buffer immediately before use. Preclinical and clinical data report a favorable safety and tolerability profile.

Disclaimer

For laboratory research use only. Not for human, veterinary, medical, or diagnostic use. Provided strictly for scientific and educational research.